Molecule Details
InChIKeyFJUKDAZEABGEIH-UHFFFAOYSA-N
Compound Name8-(3-(4-Fluorophenoxy)propyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one
Canonical SMILESO=C1NCN(c2ccccc2)C12CCN(CCCOc1ccc(F)cc1)CC2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)19
Pfam Stratification Cross-Family
Avg pChEMBL6.78
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19907
Drug NameSpiramide
CAS Number510-74-7
Groups experimental
ATC Codes nan
DescriptionSpiramide is a small molecule drug. Spiramide has a monoisotopic molecular weight of 383.2 Da.

Categories: Antidepressive Agents Central Nervous System Depressants Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists
Cross-references: BindingDB: 86525 ChEBI: 64207 CHEMBL79834 ZINC: ZINC000001846593
Target Activities (19)
Target Gene Organism Category Pfam pChEMBL Type Source
P28223 HTR2A Homo sapiens Human PF00001 8.7 IC50 ChEMBL;BindingDB
P14416 DRD2 Homo sapiens Human PF00001 8.5 Ki ChEMBL;BindingDB
P21917 DRD4 Homo sapiens Human PF00001 8.3 Ki ChEMBL
P35462 DRD3 Homo sapiens Human PF00001 7.5 Ki ChEMBL
P35372 OPRM1 Homo sapiens Human PF00001 6.8 Ki ChEMBL
P31645 SLC6A4 Homo sapiens Human PF03491 PF00209 6.7 Ki ChEMBL
P18089 ADRA2B Homo sapiens Human PF00001 6.5 Ki ChEMBL
P35368 ADRA1B Homo sapiens Human PF00001 6.5 Ki ChEMBL
P35367 HRH1 Homo sapiens Human PF00001 6.5 Ki ChEMBL
P34969 HTR7 Homo sapiens Human PF00001 6.5 Ki ChEMBL
P25100 ADRA1D Homo sapiens Human PF00001 6.4 Ki ChEMBL
P08908 HTR1A Homo sapiens Human PF00001 6.4 Ki ChEMBL
P35348 ADRA1A Homo sapiens Human PF00001 6.4 Ki ChEMBL
P50406 HTR6 Homo sapiens Human PF00001 6.4 Ki ChEMBL
Q99720 SIGMAR1 Homo sapiens Human PF04622 6.4 Ki ChEMBL
P18825 ADRA2C Homo sapiens Human PF00001 6.1 Ki ChEMBL
Q5BJF2 TMEM97 Homo sapiens Human PF05241 6.0 Ki ChEMBL
P41145 OPRK1 Homo sapiens Human PF00001 6.0 Ki ChEMBL
P41595 HTR2B Homo sapiens Human PF00001 6.0 Ki BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P28223 HTR2A 5-hydroxytryptamine receptor 2A antagonist targets
P28335 HTR2C 5-hydroxytryptamine receptor 2C antagonist targets
P41595 HTR2B 5-hydroxytryptamine receptor 2B antagonist targets