InChIKey	FJLGEFLZQAZZCD-VAWYXSNFSA-N
Compound Name	(6E)-7-(3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid
Canonical SMILES	CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.45
Source	ChEMBL

DrugBank ID	DB01095
Drug Name	Fluvastatin
CAS Number	93957-54-1
Groups	approved investigational
ATC Codes	C10AA04
Description	Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called stat...

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Categories: Agents Causing Muscle Toxicity Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Fatty Acids Heptanoic Acids Heterocyclic Compounds, Fused-Ring Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypolipidemic Agents Hypolipidemic Agents Indicated for Hyperlipidemia Indoles Lipid Modifying Agents Lipid Modifying Agents, Plain Lipid Regulating Agents Lipids OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 substrates UGT1A1 Substrates UGT1A3 substrates UGT2B7 substrates

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Cross-references: BindingDB: 50622531 ChEBI: 38562 CHEMBL2220442 ChemSpider: 4510159 Drugs Product Database (DPD): 11388 C07014 D07983 PDB: 115 PharmGKB: PA449688 PubChem:1548972 PubChem:46505668 RxCUI: 41127 Therapeutic Targets Database: DAP000554 Wikipedia: Fluvastatin ZINC: ZINC000001530639