Molecule Details
| InChIKey | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
|---|---|
| Canonical SMILES | CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@]3(O)CC |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.38 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB05482 |
|---|---|
| Drug Name | SN-38 |
| CAS Number | 86639-52-3 |
| Groups | investigational |
| ATC Codes | nan |
| Description | 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell ... |
Categories: Alkaloids Antineoplastic Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Topoisomerase I Inhibitors Topoisomerase Inhibitors
Cross-references: BindingDB: 50418088 ChEBI: 8988 CHEMBL837 ChemSpider: 94634 C11173 PDB: RS4 PubChem:104842 PubChem:175427017 Wikipedia: SN-38 ZINC: ZINC000004099013