Molecule Details
| InChIKey | FIUCLBJMUGCQTF-NSHDSACASA-N |
|---|---|
| Compound Name | 6-[[(1S)-1-(4-Chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| Canonical SMILES | C[C@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)c1ccc(Cl)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.05 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O60658 | PDE8A | Homo sapiens | Human | PF00989 PF08629 PF23198 PF00233 | 9.0 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 8.9 | IC50 | ChEMBL |
| Q9Y233 | PDE10A | Homo sapiens | Human | PF01590 PF00233 | 8.6 | IC50 | ChEMBL |
| O00408 | PDE2A | Homo sapiens | Human | PF01590 PF00233 | 8.6 | IC50 | ChEMBL |
| Q13946 | PDE7A | Homo sapiens | Human | PF00233 | 8.6 | IC50 | ChEMBL |
| O76083 | PDE9A | Homo sapiens | Human | PF00233 | 8.0 | IC50 | ChEMBL;BindingDB |
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.4 | IC50 | ChEMBL |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 6.3 | IC50 | ChEMBL |