Molecule Details
| InChIKey | FHTCHCUICJOIGJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5-(4-acetyl-1H-pyrrol-2-yl)-2-[cyclopropyl-[1-(3-methoxy-4-pyridinyl)pyrazol-4-yl]amino]-1,3-thiazole-4-carboxamide |
| Canonical SMILES | COc1cnccc1-n1cc(N(c2nc(C(N)=O)c(-c3cc(C(C)=O)c[nH]3)s2)C2CC2)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.94 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P36896 | ACVR1B | Homo sapiens | Human | PF01064 PF00069 PF08515 | 8.7 | IC50 | ChEMBL |
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 8.7 | IC50 | ChEMBL |
| Q04771 | ACVR1 | Homo sapiens | Human | PF01064 PF07714 PF08515 | 8.4 | IC50 | ChEMBL |
| P37023 | ACVRL1 | Homo sapiens | Human | PF07714 PF08515 | 7.8 | IC50 | ChEMBL |
| Q13705 | ACVR2B | Homo sapiens | Human | PF01064 PF00069 | 7.8 | IC50 | ChEMBL |
| P36894 | BMPR1A | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.2 | IC50 | ChEMBL |
| O00238 | BMPR1B | Homo sapiens | Human | PF01064 PF07714 PF08515 | 7.1 | IC50 | ChEMBL |