Molecule Details
InChIKeyFHIVNWJIENRJBH-UHFFFAOYSA-N
Compound Name3-[4-Methyl-3-(1,5,7,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-12-yl)piperidin-1-yl]-3-oxopropanenitrile
Canonical SMILESCC1CCN(C(=O)CC#N)CC1c1ncc2cnc3[nH]ccc3n12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL7.01
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 9.1 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.6 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.5 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.5 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q8IU85 CAMK1D Homo sapiens Human PF00069 6.1 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.0 Ki ChEMBL