Molecule Details
| InChIKey | FGVVTMRZYROCTH-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | [O-][n+]1ccccc1S |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.3 |
| Source | ChEMBL;TTD_MultiTarget |
2D Structure
DrugBank Annotations
| DrugBank ID | DB06815 |
|---|---|
| Drug Name | Pyrithione |
| CAS Number | 1121-31-9 |
| Groups | approved |
| ATC Codes | D11AX12 |
| Description | Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties... |
Categories: Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Dermatologicals Drugs that are Mainly Renally Excreted Gallium Radioisotopes Keratolytic Agents Miscellaneous Local Anti-infectives Sulfur Compounds
Cross-references: BindingDB: 50366038 ChEBI: 36584 CHEMBL1356238 ChemSpider: 10446934 Drugs Product Database (DPD): 662 PubChem:26041 PubChem:347827800 RxCUI: 35100 Wikipedia: Pyrithione_zinc ZINC: ZINC000000156822
Target Activities (2)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P18505 | GABRB1 | Homo sapiens | Human | PF02931 PF02932 | Clinical | TTD_MultiTarget | TTD_MultiTarget |
| P0DTD1 | rep | Severe acute respiratory syndrome coronavirus 2 | Pathogen | PF13087 PF16251 PF11501 PF12379 PF12124 PF11633 PF06471 PF06460 PF09401 PF20631 PF20633 PF20632 PF19215 PF19216 PF19219 PF19211 PF19218 PF16348 PF19217 PF19213 PF08716 PF08717 PF08710 PF08715 PF06478 PF01661 PF05409 PF00680 | 7.3 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P51787 | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | activator | targets |