Molecule Details
InChIKeyFGLPGUCHBHILNS-UHFFFAOYSA-N
Compound Name1-Pyrazin-2-yl-3-[8-(trifluoromethyl)quinolin-4-yl]urea
Canonical SMILESO=C(Nc1cnccn1)Nc1ccnc2c(C(F)(F)F)cccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Homologous
Avg pChEMBL6.66
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P49840 GSK3A Homo sapiens Human PF00069 8.2 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.8 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.1 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.0 Ki ChEMBL