1-[4-[7-Amino-3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenyl]-3-[3-(trifluoromethyl)phenyl]urea

InChIKey	`FFCFHBVSGILIJY-UHFFFAOYSA-N`
Compound Name	1-[4-[7-Amino-3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenyl]-3-[3-(trifluoromethyl)phenyl]urea
Canonical SMILES	`Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	7.26
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	8.4	Ki	ChEMBL
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	8.1	Ki	ChEMBL
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	7.9	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	7.9	Ki	ChEMBL
P16234	PDGFRA	Homo sapiens	Human	PF07679 PF25305 PF07714	7.8	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	7.8	Ki	ChEMBL
P49336	CDK8	Homo sapiens	Human	PF00069	7.6	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.5	Ki	ChEMBL
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	7.3	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	7.2	Ki	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	7.0	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.7	Ki	ChEMBL
Q07912	TNK2	Homo sapiens	Human	PF09027 PF11555 PF07714 PF22931 PF14604	6.7	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.6	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.5	Ki	ChEMBL
Q06187	BTK	Homo sapiens	Human	PF00779 PF00169 PF07714 PF00017 PF00018	6.5	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL