InChIKey	FELGMEQIXOGIFQ-UHFFFAOYSA-N
Compound Name	Ondansetron
Canonical SMILES	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	10
Pfam Stratification	Cross-Family
Avg pChEMBL	7.51
Source	BindingDB;ChEMBL

DrugBank ID	DB00904
Drug Name	Ondansetron
CAS Number	99614-02-5
Groups	approved investigational withdrawn
ATC Codes	A04AA01
Description	A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Having been developed in the 1980s by GlaxoSmithKline and approved by the U...

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Categories: Anti-Anxiety Agents Antidepressive Agents Antiemetic Serotonin 5-HT3 Receptor Antagonists Antiemetics Antiemetics and Antinauseants Carbazoles Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Imidazoles Indoles Moderate Risk QTc-Prolonging Agents Peripheral Nervous System Agents Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 3 Receptor Antagonists Serotonin 5-HT3 Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists

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Cross-references: BindingDB: 85330 ChEBI: 7773 CHEMBL46 ChemSpider: 4434 Drugs Product Database (DPD): 11104 Guide to Pharmacology: 2290 IUPHAR: 2290 C07325 D00456 PDB: S87 PharmGKB: PA450705 PubChem:4595 PubChem:46504819 RxCUI: 26225 Therapeutic Targets Database: DAP000221 Wikipedia: Ondansetron