Molecule Details
| InChIKey | FECSXNXXQKGAJO-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-N-[3,5-bis(trifluoromethyl)phenyl]-5-(1-propylpyrazol-4-yl)-4-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidine-2,4-diamine |
| Canonical SMILES | CCCn1cc(-c2cnc(Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)nc2Nc2ccc3c(c2)CNCC3)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.82 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 10.9 | IC50 | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 6.5 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.0 | IC50 | ChEMBL;BindingDB |