InChIKey	FDLYAMZZIXQODN-UHFFFAOYSA-N
Compound Name	Olaparib
Canonical SMILES	O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	11
Pfam Stratification	Homologous
Avg pChEMBL	7.23
Source	ChEMBL;BindingDB

DrugBank ID	DB09074
Drug Name	Olaparib
CAS Number	763113-22-0
Groups	approved investigational
ATC Codes	L01XK01
Description	Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and ind...

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Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (strength unknown) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (weak) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Immunosuppressive Agents MATE 1 Inhibitors MATE 2-K Inhibitors MATE inhibitors Myelosuppressive Agents Narrow Therapeutic Index Drugs OAT3/SLC22A8 Inhibitors OATP1B1/SLCO1B1 Inhibitors OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Poly (ADP-ribose) polymerase (PARP) inhibitors Poly(ADP-ribose) Polymerase Inhibitors Pyridazines UGT1A1 Inhibitors

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Cross-references: BindingDB: 27566 ChEBI: 83766 CHEMBL521686 ChemSpider: 23343272 Drugs Product Database (DPD): 22712 D09730 PDB: 09L RxCUI: 1597582 Wikipedia: Olaparib ZINC: ZINC000040430143