Molecule Details
| InChIKey | FDDDEECHVMSUSB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Sulfanilamide |
| Canonical SMILES | Nc1ccc(S(N)(=O)=O)cc1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 11 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.63 |
| Source | BindingDB;ChEMBL;TTD_MultiTarget |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00259 |
|---|---|
| Drug Name | Sulfanilamide |
| CAS Number | 63-74-1 |
| Groups | approved withdrawn |
| ATC Codes | G01AE10 J01EB06 D06BA05 |
| Description | Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline. |
Categories: Amides Amines Aniline Compounds Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Benzene Derivatives Benzenesulfonamides Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 Enzyme Inhibitors Dermatologicals Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Methemoglobinemia Associated Agents Short-Acting Antibacterial Sulfonamides Sulfanilamides Sulfonamide Antibacterial Sulfonamides Sulfonamides and trimethoprim Sulfones Sulfur Compounds
Cross-references: BindingDB: 10857 ChEBI: 45373 CHEMBL21 ChemSpider: 5142 Drugs Product Database (DPD): 8207 C07458 D08543 PDB: SAN PharmGKB: PA451545 PubChem:5333 PubChem:46508306 RxCUI: 10184 Therapeutic Targets Database: DNC001391 Wikipedia: Sulfanilamide ZINC: ZINC000000002101
Target Activities (11)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q8N1Q1 | CA13 | Homo sapiens | Human | PF00194 | 7.5 | Ki | ChEMBL;BindingDB |
| O43570 | CA12 | Homo sapiens | Human | PF00194 | 7.4 | Ki | ChEMBL;BindingDB |
| P43166 | CA7 | Homo sapiens | Human | PF00194 | 7.2 | Ki | ChEMBL;BindingDB |
| P00918 | CA2 | Homo sapiens | Human | PF00194 | 6.6 | Ki | ChEMBL;BindingDB |
| P18505 | GABRB1 | Homo sapiens | Human | PF02931 PF02932 | 6.6 | pIC50 | TTD_MultiTarget |
| Q16790 | CA9 | Homo sapiens | Human | PF00194 | 6.5 | Ki | ChEMBL;BindingDB |
| P00915 | CA1 | Homo sapiens | Human | PF00194 | 6.5 | Ki | ChEMBL;BindingDB |
| P23280 | CA6 | Homo sapiens | Human | PF00194 | 6.0 | Ki | ChEMBL;BindingDB |
| P07451 | CA3 | Homo sapiens | Human | PF00194 | 6.0 | Ki | BindingDB |
| O24855 | cynT | Helicobacter pylori (strain ATCC 700392 / 26695) | Pathogen | PF00484 | 6.4 | Ki | ChEMBL;BindingDB |
| Q3I4V7 | CAN2 | Cryptococcus neoformans | Pathogen | PF00484 | 6.1 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P0AC13 | P0AC13 | Dihydropteroate synthase | inhibitor | targets |