Molecule Details
InChIKeyFBCQEUMZZNVQKD-UHFFFAOYSA-N
Canonical SMILESO=C(c1ccc(O)c(F)c1)N(c1ccc(O)cc1)c1ccc(F)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.74
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB14969
Drug NameGTX-758
CAS Number938067-78-8
Groups investigational
ATC Codes nan
DescriptionGTX-758 is under investigation in clinical trial NCT01420861 (GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer).
Categories: Acids, Carbocyclic Amides Benzene Derivatives Benzoates
Cross-references: BindingDB: 102986 CHEMBL3545017 ChemSpider: 34954411 Wikipedia: GTx-758 ZINC: ZINC000096173894
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q92731 ESR2 Homo sapiens Human PF12497 PF00104 PF00105 7.8 Ki ChEMBL;BindingDB
P03372 ESR1 Homo sapiens Human PF12743 PF00104 PF02159 PF00105 7.7 Ki ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P03372 ESR1 Estrogen receptor modulator targets