Molecule Details
InChIKeyFABPRXSRWADJSP-MEDUHNTESA-N
Compound NameMoxifloxacin
Canonical SMILESCOc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL6.38
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00218
Drug NameMoxifloxacin
CAS Number151096-09-2
Groups approved investigational
ATC Codes S01AE07 J01MA14
DescriptionMoxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.

Categories: 4-Quinolones Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Fluoroquinolone Antibacterial Fluoroquinolones Heterocyclic Compounds, Fused-Ring Moderate Risk QTc-Prolonging Agents Ophthalmologicals QTc Prolonging Agents Quinolines Quinolone Antimicrobial Quinolones Sensory Organs Topoisomerase II Inhibitors Topoisomerase Inhibitors
Cross-references: BindingDB: 50366824 ChEBI: 63611 CHEMBL32 ChemSpider: 134802 Drugs Product Database (DPD): 12034 C07663 D08237 PDB: MFX PharmGKB: PA450555 PubChem:152946 PubChem:46508509 RxCUI: 139462 Therapeutic Targets Database: DAP000158 Wikipedia: Moxifloxacin ZINC: ZINC000003826253
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P0AES4 gyrA Escherichia coli (strain K12) Pathogen PF03989 PF00521 6.5 IC50 ChEMBL
P0AES6 gyrB Escherichia coli (strain K12) Pathogen PF00204 PF00986 PF21249 PF18053 PF02518 PF01751 6.5 IC50 ChEMBL
P0C1U9 parC Staphylococcus aureus Pathogen PF03989 PF00521 6.1 IC50 ChEMBL
DrugBank Target Actions (7)
Target Gene Target Name Action Type
P05177 CYP1A2 Cytochrome P450 1A2 inhibitor enzymes
P11388 TOP2A DNA topoisomerase 2-alpha inhibitor targets
P27169 P27169 Serum paraoxonase/arylesterase 1 inhibitor targets
P43700 P43700 DNA gyrase subunit A inhibitor targets
P43702 P43702 DNA topoisomerase 4 subunit A inhibitor targets
P0A0K8 gyrB DNA gyrase subunit B modulator targets
P20831 gyrA DNA gyrase subunit A modulator targets