Molecule Details
InChIKeyDYEJYFAQYRMVFS-UHFFFAOYSA-N
Compound Name4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,5-difluorophenol
Canonical SMILESCC(C)n1nc(-c2cc(F)c(O)cc2F)c2c(N)ncnc21
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL7.02
SourceChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
P42345 MTOR Homo sapiens Human PF02259 PF02260 PF08771 PF23593 PF11865 PF00454 7.3 pIC50 TTD_MultiTarget
P78527 PRKDC Homo sapiens Human PF20500 PF20502 PF08163 PF19704 PF02259 PF02260 PF00454 7.3 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 7.3 pIC50 TTD_MultiTarget
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.3 IC50 ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 7.1 IC50 ChEMBL
O00329 PIK3CD Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 7.0 IC50 ChEMBL
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 6.9 IC50 ChEMBL
P42336 PIK3CA Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 6.5 IC50 ChEMBL
Q9UBF8 PI4KB Homo sapiens Human PF00454 PF21245 6.3 IC50 ChEMBL