Molecule Details
InChIKeyDTMZXHDQZQLTHA-UHFFFAOYSA-N
Compound Name2-({2-[(3-Fluorophenyl)amino]pyrimidin-4-yl}amino)benzoic acid
Canonical SMILESO=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL7.05
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9H2X6 HIPK2 Homo sapiens Human PF00069 8.2 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.7 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 7.5 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.5 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.5 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.3 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.2 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 7.1 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.9 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.7 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.1 Ki ChEMBL