Molecule Details
| InChIKey | DTDZLJHKVNTQGZ-GOSISDBHSA-N |
|---|---|
| Compound Name | Azd7545 |
| Canonical SMILES | CN(C)C(=O)c1ccc(S(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.92 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB07403 |
|---|---|
| Drug Name | 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 50236535 CHEMBL1231132 ChemSpider: 20572552 PDB: AZX PubChem:16741245 PubChem:99443874 ZINC: ZINC000001547088
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q15118 | PDK1 | Homo sapiens | Human | PF10436 PF02518 | 7.4 | IC50 | ChEMBL;BindingDB |
| Q15119 | PDK2 | Homo sapiens | Human | PF10436 PF02518 | 7.1 | IC50 | ChEMBL;BindingDB |
| Q15120 | PDK3 | Homo sapiens | Human | PF10436 PF02518 | 6.9 | IC50 | ChEMBL |
| Q16654 | PDK4 | Homo sapiens | Human | PF10436 PF02518 | 6.3 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q15118 | PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | binder | targets |