2,10-Dioxo-11-(2''-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-oxo-2-piperazin-1-yl-ethyl)-amide]

InChIKey	`DQLDJYJWPVFOFC-REUBFRLUSA-N`
Compound Name	2,10-Dioxo-11-(2''-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-oxo-2-piperazin-1-yl-ethyl)-amide]
Canonical SMILES	`O=C1NCCCC[C@@H](C(=O)NCC(=O)N2CCNCC2)NC(=O)[C@H](Cc2ccc(-c3ccccc3C(F)(F)F)cc2)[C@@H](C(=O)NO)CCCO1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	6.54
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P45452	MMP13	Homo sapiens	Human	PF00045 PF00413 PF01471	7.3	Ki	ChEMBL;BindingDB
P09237	MMP7	Homo sapiens	Human	PF00413 PF01471	6.8	Ki	ChEMBL;BindingDB
P39900	MMP12	Homo sapiens	Human	PF00045 PF00413 PF01471	6.4	Ki	ChEMBL;BindingDB
P08254	MMP3	Homo sapiens	Human	PF00045 PF00413 PF01471	6.2	Ki	ChEMBL;BindingDB
P22894	MMP8	Homo sapiens	Human	PF00045 PF00413 PF01471	6.2	Ki	ChEMBL;BindingDB
P08253	MMP2	Homo sapiens	Human	PF00040 PF00045 PF00413	6.2	Ki	ChEMBL;BindingDB
P18843	nadE	Escherichia coli (strain K12)	Pathogen	PF02540	6.8	pIC50	TTD_MultiTarget