InChIKey	DQCKKXVULJGBQN-XFWGSAIBSA-N
Compound Name	Naltrexone
Canonical SMILES	O=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	8.0
Source	BindingDB;ChEMBL

DrugBank ID	DB00704
Drug Name	Naltrexone
CAS Number	16590-41-3
Groups	approved investigational vet_approved
ATC Codes	N02AA56 N07BB04 A08AA62
Description	Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alc...

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Categories: Agents Causing Muscle Toxicity Alcohol Deterrents Alimentary Tract and Metabolism Alkaloids Analgesics Antiobesity Preparations, Excl. Diet Products Central Nervous System Agents Centrally Acting Antiobesity Products Drugs Used in Addictive Disorders Drugs Used in Alcohol Dependence Hepatotoxic Agents Heterocyclic Compounds, Fused-Ring Morphinans Natural Opium Alkaloids Nervous System Opiate Alkaloids Opiate Antagonists Opioid Antagonists Opioids Peripheral Nervous System Agents Phenanthrenes Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome UGT1A1 Substrates

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Cross-references: BindingDB: 60212 ChEBI: 7465 CHEMBL19019 ChemSpider: 4514524 Drugs Product Database (DPD): 20300 C07253 D05113 PharmGKB: PA450588 PubChem:5360515 PubChem:46505333 RxCUI: 7243 Therapeutic Targets Database: DAP000379 Wikipedia: Naltrexone ZINC: ZINC000000001773