Molecule Details
InChIKeyDPWPWRLQFGFJFI-UHFFFAOYSA-N
Compound NamePargyline
Canonical SMILESC#CCN(C)Cc1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.42
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01626
Drug NamePargyline
CAS Number555-57-7
Groups approved
ATC Codes C02LL01 C02KC01
DescriptionPargyline is a monoamine oxidase inhibitor with antihypertensive properties.

Categories: Agents that produce hypertension Agents that reduce seizure threshold Amines Antidepressive Agents Antihypertensive Agents Benzene Derivatives Benzyl Compounds Benzylamines Cardiovascular Agents Central Nervous System Depressants Enzyme Inhibitors MAO Inhibitors and Diuretics Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Monoamine Oxidase Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50172756 ChEBI: 7930 CHEMBL673 ChemSpider: 4526 C07414 D08453 PharmGKB: PA450797 PubChem:4688 PubChem:46507368 RxCUI: 7930 Therapeutic Targets Database: DAP000580 Wikipedia: Pargyline ZINC: ZINC000053084618
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P21397 MAOA Homo sapiens Human PF01593 7.9 IC50 ChEMBL;BindingDB
P27338 MAOB Homo sapiens Human PF01593 6.9 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P21397 MAOA Amine oxidase [flavin-containing] A inhibitor targets
P27338 MAOB Amine oxidase [flavin-containing] B inhibitor targets