2-[(2S,3S)-1-(2-amino-5,5-dioxo-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)-3-methylazetidin-2-yl]-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

InChIKey	`DPHFLPMHQWTKGY-LRDDRELGSA-N`
Compound Name	2-[(2S,3S)-1-(2-amino-5,5-dioxo-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)-3-methylazetidin-2-yl]-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one
Canonical SMILES	`C[C@H]1CN(c2nc(N)nc3c2S(=O)(=O)CC3)[C@@H]1c1nn2ccc(Cl)c2c(=O)n1-c1ccccc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	8.44
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P48736	PIK3CG	Homo sapiens	Human	PF00454 PF00792 PF00794 PF00613 PF19710	8.5	IC50	ChEMBL;BindingDB
O00329	PIK3CD	Homo sapiens	Human	PF00454 PF00792 PF02192 PF00794 PF00613	8.4	IC50	ChEMBL
P27986	PIK3R1	Homo sapiens	Human	PF16454 PF00620 PF00017	8.4	IC50	ChEMBL;BindingDB