Molecule Details
InChIKeyDPEXRCOBPACFOO-UHFFFAOYSA-N
Compound NameWee1 Inhibitor
Canonical SMILESO=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)36
Pfam Stratification Cross-Family
Avg pChEMBL6.86
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (36)
Target Gene Organism Category Pfam pChEMBL Type Source
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 8.9 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 8.4 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 8.2 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 8.1 Ki ChEMBL
P30291 WEE1 Homo sapiens Human PF00069 8.0 IC50 ChEMBL;BindingDB
Q02750 MAP2K1 Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.6 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.5 Ki ChEMBL
P36507 MAP2K2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 7.0 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 7.0 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.8 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.8 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.7 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.6 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.6 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.5 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.4 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.3 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.2 Ki ChEMBL
Q8IU85 CAMK1D Homo sapiens Human PF00069 6.2 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 6.0 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.0 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9Y463 DYRK1B Homo sapiens Human PF00069 6.0 Ki ChEMBL