InChIKey	DOMXUEMWDBAQBQ-WEVVVXLNSA-N
Compound Name	Terbinafine
Canonical SMILES	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.89
Source	ChEMBL;BindingDB

DrugBank ID	DB00857
Drug Name	Terbinafine
CAS Number	91161-71-6
Groups	approved investigational vet_approved
ATC Codes	D01AE15 D01BA02
Description	Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase...

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Categories: Agents Causing Muscle Toxicity Allylamine Antifungal Allylamines Anti-Infective Agents Antifungal Agents Antifungals for Dermatological Use Antifungals for Systemic Use Antifungals for Topical Use Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Naphthalenes

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Cross-references: BindingDB: 50018518 ChEBI: 9448 CHEMBL822 ChemSpider: 1266005 Drugs Product Database (DPD): 11385 C08079 D02375 PharmGKB: PA451614 PubChem:1549008 PubChem:46508519 RxCUI: 37801 Therapeutic Targets Database: DAP000753 Wikipedia: Terbinafine ZINC: ZINC000001530981