Molecule Details
| InChIKey | DMULVCHRPCFFGV-UHFFFAOYSA-N |
|---|---|
| Compound Name | N,N-Dimethyltryptamine |
| Canonical SMILES | CN(C)CCc1c[nH]c2ccccc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 16 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.55 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01488 |
|---|---|
| Drug Name | Dimethyltryptamine |
| CAS Number | 61-50-7 |
| Groups | illicit investigational |
| ATC Codes | nan |
| Description | An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an antagonist at others. |
Categories: Amines Antidepressive Agents Biogenic Amines Biogenic Monoamines Central Nervous System Agents Central Nervous System Depressants Hallucinogens Heterocyclic Compounds, Fused-Ring Indoles Neurotransmitter Agents Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists Tryptamines
Cross-references: BindingDB: 50026868 ChEBI: 28969 CHEMBL12420 ChemSpider: 5864 Guide to Pharmacology: 141 IUPHAR: 141 C08302 PDB: A1AFV PharmGKB: PA166299581 PubChem:6089 PubChem:46507463 Wikipedia: Dimethyltryptamine ZINC: ZINC000000897457
Target Activities (16)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P34969 | HTR7 | Homo sapiens | Human | PF00001 | 7.1 | Ki | ChEMBL;BindingDB |
| P28221 | HTR1D | Homo sapiens | Human | PF00001 | 7.0 | Ki | BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 7.0 | Ki | ChEMBL;BindingDB |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 7.0 | Ki | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 6.6 | Ki | BindingDB |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 6.6 | Ki | ChEMBL;BindingDB |
| P21728 | DRD1 | Homo sapiens | Human | PF00001 | 6.6 | Ki | BindingDB |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.5 | Ki | ChEMBL;BindingDB |
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 6.4 | IC50 | ChEMBL |
| P35348 | ADRA1A | Homo sapiens | Human | PF00001 | 6.4 | IC50 | ChEMBL |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.4 | Ki | ChEMBL;BindingDB |
| P28566 | HTR1E | Homo sapiens | Human | PF00001 | 6.3 | Ki | BindingDB |
| P50406 | HTR6 | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL;BindingDB |
| P47898 | HTR5A | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| Q9Y2I1 | NISCH | Homo sapiens | Human | PF25625 PF23142 PF00787 | 6.2 | Ki | BindingDB |
| P35368 | ADRA1B | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL;BindingDB |