Molecule Details
| InChIKey | DMDGGSIALPNSEE-UHFFFAOYSA-N |
|---|---|
| Compound Name | Hydroflumethiazide |
| Canonical SMILES | NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.41 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00774 |
|---|---|
| Drug Name | Hydroflumethiazide |
| CAS Number | 135-09-1 |
| Groups | approved withdrawn |
| ATC Codes | C03AA02 G01AE10 C03AH02 C03AB02 |
| Description | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) |
Categories: Amides Antihypertensive Agents Benzothiadiazines Cardiovascular Agents Diuretics Drugs causing inadvertant photosensitivity Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Heterocyclic Compounds, Fused-Ring Hypotensive Agents Increased Diuresis Membrane Transport Modulators Natriuretic Agents OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates Photosensitizing Agents Sodium Chloride Symporter Inhibitors Sulfonamides Sulfones Sulfur Compounds Thiazides
Cross-references: BindingDB: 25897 ChEBI: 5784 CHEMBL1763 ChemSpider: 3521 C07763 D00654 PDB: HFZ PharmGKB: PA164752557 PubChem:3647 PubChem:46505220 RxCUI: 5495 Therapeutic Targets Database: DAP000747 Wikipedia: Hydroflumethiazide ZINC: ZINC000000897225
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O43570 | CA12 | Homo sapiens | Human | PF00194 | 6.5 | Ki | BindingDB |
| Q9ULX7 | CA14 | Homo sapiens | Human | PF00194 | 6.4 | Ki | BindingDB |
| Q16790 | CA9 | Homo sapiens | Human | PF00194 | 6.4 | Ki | BindingDB |
| Q9Y2D0 | CA5B | Homo sapiens | Human | PF00194 | 6.4 | Ki | BindingDB |
| P00918 | CA2 | Homo sapiens | Human | PF00194 | 6.4 | Ki | BindingDB |
| P43166 | CA7 | Homo sapiens | Human | PF00194 | 6.4 | Ki | BindingDB |
DrugBank Target Actions (14)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P02768 | ALB | Albumin | binder | carriers |
| P05023 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | inducer | targets |
| Q12791 | KCNMA1 | Calcium-activated potassium channel subunit alpha-1 | inducer | targets |
| O43570 | CA12 | Carbonic anhydrase 12 | inhibitor | targets |
| P00915 | CA1 | Carbonic anhydrase 1 | inhibitor | targets |
| P00918 | CA2 | Carbonic anhydrase 2 | inhibitor | targets |
| P22748 | CA4 | Carbonic anhydrase 4 | inhibitor | targets |
| P43166 | CA7 | Carbonic anhydrase 7 | inhibitor | targets |
| Q13621 | Q13621 | Solute carrier family 12 member 1 | inhibitor | targets |
| Q16790 | CA9 | Carbonic anhydrase 9 | inhibitor | targets |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | inhibitor | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | inhibitor | transporters |
| Q4U2R8 | SLC22A6 | Solute carrier family 22 member 6 | substrate | transporters |
| Q8TCC7 | SLC22A8 | Organic anion transporter 3 | substrate | transporters |