Molecule Details
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N
Compound NameKetoprofen
Canonical SMILESCC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.3
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01009
Drug NameKetoprofen
CAS Number22071-15-4
Groups approved investigational vet_approved
ATC Codes M01AE03 M02AA10 M01AE53
DescriptionKetoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Peptides, and Proteins Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Arylpropionic acid NSAIDS Cyclooxygenase Inhibitors Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted Enzyme Inhibitors Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors Other Nonsteroidal Anti-inflammatory Agents Peripheral Nervous System Agents Phenylpropionates Photosensitizing Agents Propionates Sensory System Agents Topical Products for Joint and Muscular Pain UGT1A1 Substrates
Cross-references: BindingDB: 50022271 ChEBI: 6128 CHEMBL571 ChemSpider: 3693 Drugs Product Database (DPD): 2327 C01716 D00132 PharmGKB: PA450149 PubChem:3825 PubChem:46505715 RxCUI: 6142 Therapeutic Targets Database: DAP000623 Wikipedia: Ketoprofen
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P23219 PTGS1 Homo sapiens Human PF03098 7.6 IC50 ChEMBL;BindingDB
G3V5T7 KRAS Homo sapiens Human PF00071 7.5 Ki BindingDB
P35354 PTGS2 Homo sapiens Human PF03098 6.8 IC50 ChEMBL;BindingDB
DrugBank Target Actions (14)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P10632 CYP2C8 Cytochrome P450 2C8 inhibitor enzymes
P11712 CYP2C9 Cytochrome P450 2C9 inhibitor enzymes
P11712 CYP2C9 Cytochrome P450 2C9 substrate enzymes
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 substrate enzymes
P23219 PTGS1 Prostaglandin G/H synthase 1 inhibitor targets
P35354 PTGS2 Prostaglandin G/H synthase 2 inhibitor targets
P25024 CXCR1 C-X-C chemokine receptor type 1 other targets
O15439 O15439 ATP-binding cassette sub-family C member 4 inhibitor transporters
P46721 P46721 Solute carrier organic anion transporter family member 1A2 inhibitor transporters
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 inhibitor transporters
Q9NSA0 SLC22A11 Solute carrier family 22 member 11 inhibitor transporters
Q9Y694 Q9Y694 Solute carrier family 22 member 7 inhibitor transporters