Molecule Details
| InChIKey | DKYWVDODHFEZIM-NSHDSACASA-N |
|---|---|
| Compound Name | Dexketoprofen |
| Canonical SMILES | C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.72 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09214 |
|---|---|
| Drug Name | Dexketoprofen |
| CAS Number | 22161-81-5 |
| Groups | approved investigational withdrawn |
| ATC Codes | M02AA27 N02AJ14 M01AE17 |
| Description | Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties [L1298]. |
Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Alcohols Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Central Nervous System Agents Drugs that are Mainly Renally Excreted Glycols Musculo-Skeletal System Nephrotoxic agents Nervous System Non COX-2 selective NSAIDS Peripheral Nervous System Agents Phenylpropionates Propionates Propylene Glycols Sensory System Agents Topical Products for Joint and Muscular Pain
Cross-references: BindingDB: 50088570 ChEBI: 76128 CHEMBL75435 ChemSpider: 580922 D07269 PDB: 9KL PharmGKB: PA166049175 PubChem:667550 PubChem:310265121 RxCUI: 237162 Wikipedia: Dexketoprofen ZINC: ZINC000000005560
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P23219 | PTGS1 | Homo sapiens | Human | PF03098 | 8.7 | IC50 | ChEMBL;BindingDB |
| P35354 | PTGS2 | Homo sapiens | Human | PF03098 | 7.6 | IC50 | ChEMBL;BindingDB |
| P25024 | CXCR1 | Homo sapiens | Human | PF00001 | 7.3 | IC50 | ChEMBL |
| P25025 | CXCR2 | Homo sapiens | Human | PF00001 | 7.3 | IC50 | ChEMBL;BindingDB |