Molecule Details
InChIKeyDKSNLQYRZJKYOC-UHFFFAOYSA-N
Compound Name1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3,4-dimethylphenyl)urea
Canonical SMILESCc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)51
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (51)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 9.6 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 8.6 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q9UBE8 NLK Homo sapiens Human PF00069 8.3 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.9 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.9 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.8 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.4 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.4 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 7.4 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 7.3 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.3 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.1 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.1 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.9 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.9 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.9 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.9 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.9 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.8 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.7 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.7 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.7 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.6 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.5 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.5 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.4 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.3 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.3 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.3 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.1 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.1 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.1 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.1 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL