Molecule Details
| InChIKey | DKNWSYNQZKUICI-UHFFFAOYSA-N |
|---|---|
| Compound Name | Amantadine |
| Canonical SMILES | NC12CC3CC(CC(C3)C1)C2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.1 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00915 |
|---|---|
| Drug Name | Amantadine |
| CAS Number | 768-94-5 |
| Groups | approved investigational |
| ATC Codes | N04BB01 |
| Description | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an ... |
Categories: Adamantane Derivatives Adamantanes Analgesics Analgesics, Non-Narcotic Anti-Dyskinesia Agents Anti-Infective Agents Anti-Parkinson Drugs Anticholinergic Agents Antiviral Agents Bridged-Ring Compounds Central Nervous System Agents Dopamine Agents Drugs that are Mainly Renally Excreted Influenza A M2 Protein Inhibitor M2 Protein Inhibitors NMDA Receptor Antagonists Nervous System Neurotransmitter Agents Nicotinic Antagonists OCT1 inhibitors OCT1 substrates OCT2 Inhibitors OCT2 Substrates Peripheral Nervous System Agents Potential QTc-Prolonging Agents QTc Prolonging Agents Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 50033369 ChEBI: 2618 CHEMBL660 ChemSpider: 2045 Drugs Product Database (DPD): 9905 C06818 PharmGKB: PA448360 PubChem:2130 PubChem:46507081 RxCUI: 620 Therapeutic Targets Database: DAP000781 Wikipedia: Amantadine ZINC: ZINC000000968256
Target Activities (2)
DrugBank Target Actions (12)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P20711 | DDC | Aromatic-L-amino-acid decarboxylase | inducer | enzymes |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | inhibitor | enzymes |
| P14416 | DRD2 | D(2) dopamine receptor | agonist | targets |
| P32297 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | antagonist | targets |
| P36544 | CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7 | antagonist | targets |
| P43681 | CHRNA4 | Neuronal acetylcholine receptor subunit alpha-4 | antagonist | targets |
| Q8TCU5 | GRIN3A | Glutamate receptor ionotropic, NMDA 3A | antagonist | targets |
| P21430 | P21430 | Matrix protein 2 | inhibitor | targets |
| O15244 | SLC22A2 | Solute carrier family 22 member 2 | inhibitor | transporters |
| O15245 | SLC22A1 | Solute carrier family 22 member 1 | inhibitor | transporters |
| O15244 | SLC22A2 | Solute carrier family 22 member 2 | substrate | transporters |
| O15245 | SLC22A1 | Solute carrier family 22 member 1 | substrate | transporters |