Molecule Details
| InChIKey | DKBIFPXBCXSLNM-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-{3-[2-(1H-Imidazol-1-yl)ethoxy]phenyl}-3-(morpholin-4-ylcarbonyl)-1,4-dihydrothiochromeno[4,3-c]pyrazole 5,5-dioxide |
| Canonical SMILES | O=C(c1nn(-c2cccc(OCCn3ccnc3)c2)c2c1CS(=O)(=O)c1ccccc1-2)N1CCOCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.75 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O00329 | PIK3CD | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 6.8 | IC50 | ChEMBL |
| O00459 | PIK3R2 | Homo sapiens | Human | PF16454 PF00620 PF00017 | 6.8 | IC50 | ChEMBL |
| P27986 | PIK3R1 | Homo sapiens | Human | PF16454 PF00620 PF00017 | 6.8 | IC50 | ChEMBL |
| P42336 | PIK3CA | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 6.8 | IC50 | ChEMBL;BindingDB |
| P42338 | PIK3CB | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 6.8 | IC50 | ChEMBL |
| P48736 | PIK3CG | Homo sapiens | Human | PF00454 PF00792 PF00794 PF00613 PF19710 | 6.8 | IC50 | ChEMBL |
| Q8WYR1 | PIK3R5 | Homo sapiens | Human | PF10486 | 6.8 | IC50 | ChEMBL |
| Q92569 | PIK3R3 | Homo sapiens | Human | PF16454 PF00017 | 6.8 | IC50 | ChEMBL |