Molecule Details
InChIKeyDJOJKIGNNDWGRS-UHFFFAOYSA-N
Compound Name6-Methyl-5-(3-phenylmethoxyphenyl)-7-(4-pyrrolidin-1-ylcyclohexyl)pyrrolo[2,3-d]pyrimidin-4-amine
Canonical SMILESCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1C1CCC(N2CCCC2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL6.5
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.0 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.0 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.8 Ki ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 6.7 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.3 Ki ChEMBL
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 6.3 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.3 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.2 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL