Molecule Details
InChIKeyDHCOPPHTVOXDKU-UHFFFAOYSA-N
Compound NameTofimilast
Canonical SMILESCCc1nn(C2CCCC2)c2c1CCn1c(-c3cccs3)nnc1-2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL7.81
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB11681
Drug NameTofimilast
CAS Number185954-27-2
Groups investigational
ATC Codes nan
DescriptionTofimilast has been used in trials studying the treatment of Asthma and Pulmonary Disease, Chronic Obstructive.

Categories: Heterocyclic Compounds, Fused-Ring
Cross-references: BindingDB: 50202528 CHEMBL217899 ChemSpider: 8071932 PubChem:9896267 PubChem:347828048 ZINC: ZINC000000021914
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q07343 PDE4B Homo sapiens Human PF18100 PF00233 7.9 IC50 ChEMBL;BindingDB
Q08499 PDE4D Homo sapiens Human PF18100 PF00233 7.9 IC50 ChEMBL;BindingDB
P27815 PDE4A Homo sapiens Human PF18100 PF00233 7.6 IC50 ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P27815 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A inhibitor targets
Q07343 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B inhibitor targets
Q08499 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D inhibitor targets