Molecule Details
| InChIKey | DEZZLWQELQORIU-RELWKKBWSA-N |
|---|---|
| Compound Name | Gdc-0879 |
| Canonical SMILES | OCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.4 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P15056 | BRAF | Homo sapiens | Human | PF00130 PF07714 PF02196 | 9.8 | IC50 | ChEMBL;BindingDB |
| P04049 | RAF1 | Homo sapiens | Human | PF00130 PF07714 PF02196 | 8.7 | Kd | ChEMBL |
| P27361 | MAPK3 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL |
| P28482 | MAPK1 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL |
| P49674 | CSNK1E | Homo sapiens | Human | PF00069 | 6.9 | Kd | ChEMBL |
| Q56UN5 | MAP3K19 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL |
| Q8N4C8 | MINK1 | Homo sapiens | Human | PF00780 PF00069 | 6.0 | Kd | ChEMBL |