Molecule Details
| InChIKey | DBSMLQTUDJVICQ-CJODITQLSA-N |
|---|---|
| Canonical SMILES | Nc1nc2cc(CC[C@H]3C[C@@H](n4ccc5c(N)ncnc54)[C@H](O)[C@@H]3O)ccc2cc1Br |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 9.75 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB21480 |
|---|---|
| Drug Name | Onametostat |
| CAS Number | 2086772-26-9 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Onametostat is a small molecule drug. The usage of the INN stem '-metostat' in the name indicates that Onametostat is a histone N-methyltransferase inhibitor. Onametostat is under investigation in clinical trial NCT06788509 (A Rollover Study for Continued Study Treatment and Ongoing Safety Monitorin... |
Categories: Enzyme Inhibitors
Cross-references: BindingDB: 50462572 CHEMBL4249337 PDB: K8N
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| O14744 | PRMT5 | Protein arginine N-methyltransferase 5 | inhibitor | targets |