Molecule Details
InChIKeyDAYKLWSKQJBGCS-NRFANRHFSA-N
Canonical SMILESCO[C@@H](Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2ccsc12)C(=O)O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.57
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08915
Drug NameAleglitazar
CAS Number475479-34-6
Groups investigational
ATC Codes nan
DescriptionAleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase III clinical trial called ALECARDIO. It is being investigated for use in patients with type II diabetes to reduce their risks of cardiovascular mortality and morbidity. Aleglitazar is an agonist at ...

Categories: Sulfur Compounds
Cross-references: BindingDB: 50277897 CHEMBL519504 ChemSpider: 8450255 D08845 PDB: RO7 PubChem:10274777 PubChem:175427152 Wikipedia: Aleglitazar ZINC: ZINC000049573657
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P37231 PPARG Homo sapiens Human PF00104 PF12577 PF00105 7.7 IC50 ChEMBL;BindingDB
Q07869 PPARA Homo sapiens Human PF00104 PF00105 7.4 IC50 ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P37231 PPARG Peroxisome proliferator-activated receptor gamma agonist targets
Q07869 PPARA Peroxisome proliferator-activated receptor alpha agonist targets
Q15788 NCOA1 Nuclear receptor coactivator 1 binder targets