Molecule Details
InChIKeyCZWJLLBPWLUINU-UHFFFAOYSA-N
Compound Name10,14-Dimethyl-9-oxo-3-(trifluoromethyl)-4,5,10,13,14,19,21-heptazapentacyclo[15.5.2.12,5.012,16.020,23]pentacosa-1(22),2(25),3,12,15,17(24),18,20(23)-octaene-15-carbonitrile
Canonical SMILESCN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.87
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13627 DYRK1A Homo sapiens Human PF00069 7.9 IC50 ChEMBL;BindingDB
Q9Y463 DYRK1B Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P49759 CLK1 Homo sapiens Human PF00069 7.5 Kd ChEMBL
Q9UKE5 TNIK Homo sapiens Human PF00780 PF00069 7.1 IC50 ChEMBL;BindingDB
P45985 MAP2K4 Homo sapiens Human PF00069 6.8 IC50 ChEMBL;BindingDB
O00141 SGK1 Homo sapiens Human PF00069 PF00433 6.7 IC50 ChEMBL;BindingDB
Q15746 MYLK Homo sapiens Human PF16620 PF00041 PF07679 PF00069 6.5 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.5 IC50 ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.3 IC50 ChEMBL;BindingDB
Q6P2M8 PNCK Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB