N-{4-[1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

InChIKey	`CZVVMRNEBRFYTL-UHFFFAOYSA-N`
Compound Name	N-{4-[1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea
Canonical SMILES	`CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	9
Pfam Stratification	Cross-Family
Avg pChEMBL	6.97
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q96GD4	AURKB	Homo sapiens	Human	PF00069	8.7	IC50	ChEMBL;BindingDB
Q9NQS7	INCENP	Homo sapiens	Human	PF03941 PF12178	8.7	IC50	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	6.8	IC50	ChEMBL;BindingDB
O75716	STK16	Homo sapiens	Human	PF00069	6.5	pIC50	TTD_MultiTarget
P06729	CD2	Homo sapiens	Human	PF05790 PF07686	6.5	pIC50	TTD_MultiTarget
P08581	MET	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	6.5	pIC50	TTD_MultiTarget
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	IC50	ChEMBL;BindingDB
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.4	IC50	ChEMBL;BindingDB
O14965	AURKA	Homo sapiens	Human	PF00069	6.2	IC50	ChEMBL;BindingDB