Molecule Details
| InChIKey | CZUHYAFUFAOCJF-UHFFFAOYSA-N |
|---|---|
| Compound Name | [4-[(2,4-Diaminopteridin-6-yl)methylamino]phenyl]-phenylmethanone |
| Canonical SMILES | Nc1nc(N)c2nc(CNc3ccc(C(=O)c4ccccc4)cc3)cnc2n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.51 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q581W1 | Tb08.26N11.790 | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | Pathogen | PF13561 | 9.0 | IC50 | ChEMBL |
| Q01782 | PTR1 | Leishmania major | Pathogen | PF00106 PF13561 | 7.5 | IC50 | ChEMBL |
| Q582G3 | Tb07.10C21.550 | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | Pathogen | PF00186 PF00303 | 6.0 | IC50 | ChEMBL |