3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione

InChIKey	`CZGMEOAMQWAJOY-UHFFFAOYSA-N`
Compound Name	3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
Canonical SMILES	`COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	15
Pfam Stratification	Cross-Family
Avg pChEMBL	6.99
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P11802	CDK4	Homo sapiens	Human	PF00069	8.6	pIC50	TTD_MultiTarget
P35916	FLT4	Homo sapiens	Human	PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	8.3	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	8.1	IC50	ChEMBL;BindingDB
P24941	CDK2	Homo sapiens	Human	PF00069	7.6	pIC50	TTD_MultiTarget
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	7.3	IC50	ChEMBL;BindingDB
Q02763	TEK	Homo sapiens	Human	PF00041 PF10430 PF07714	7.3	pIC50	TTD_MultiTarget
P49841	GSK3B	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL;BindingDB
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	6.7	IC50	ChEMBL;BindingDB
Q02161	RHD	Homo sapiens	Human	PF00909	6.6	pIC50	TTD_MultiTarget
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	6.2	IC50	ChEMBL;BindingDB
P06729	CD2	Homo sapiens	Human	PF05790 PF07686	6.1	pIC50	TTD_MultiTarget
Q05397	PTK2	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	6.1	IC50	ChEMBL;BindingDB
P16234	PDGFRA	Homo sapiens	Human	PF07679 PF25305 PF07714	6.0	IC50	ChEMBL;BindingDB
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.0	IC50	ChEMBL;BindingDB
P04626	ERBB2	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	Clinical	TTD_MultiTarget	TTD_MultiTarget