Molecule Details
| InChIKey | CXQHYVUVSFXTMY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Foretinib |
| Canonical SMILES | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 154 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.24 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12307 |
|---|---|
| Drug Name | Foretinib |
| CAS Number | 849217-64-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally available small molecule compound designed to target multiple RTKs implicated in the development, prog... |
Categories: Amides Amines Aniline Compounds Heterocyclic Compounds, Fused-Ring Receptors, Vascular Endothelial Growth Factor, antagonists & inhibitors Tyrosine Kinase Inhibitors
Cross-references: BindingDB: 50399540 ChEBI: 91418 CHEMBL1230609 ChemSpider: 24608641 PDB: 88Z PubChem:42642645 PubChem:347828572 Wikipedia: Foretinib ZINC: ZINC000043204048
Target Activities (154)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q08345 | DDR1 | Homo sapiens | Human | PF21114 PF00754 PF07714 | 9.7 | Kd | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 9.6 | Kd | ChEMBL |
| O94804 | STK10 | Homo sapiens | Human | PF00069 PF12474 | 9.3 | Kd | ChEMBL |
| P35590 | TIE1 | Homo sapiens | Human | PF00041 PF00047 PF07714 | 9.1 | Kd | ChEMBL |
| P29320 | EPHA3 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 | 9.0 | Kd | ChEMBL |
| Q02763 | TEK | Homo sapiens | Human | PF00041 PF10430 PF07714 | 9.0 | IC50 | ChEMBL;BindingDB |
| Q9UF33 | EPHA6 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 9.0 | Kd | ChEMBL |
| P07949 | RET | Homo sapiens | Human | PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 | 8.8 | Kd | ChEMBL |
| P08581 | MET | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 8.8 | IC50 | ChEMBL;BindingDB |
| P07333 | CSF1R | Homo sapiens | Human | PF00047 PF25305 PF07714 | 8.7 | Kd | ChEMBL |
| P29322 | EPHA8 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 8.7 | Kd | ChEMBL |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 8.7 | Kd | ChEMBL |
| P35916 | FLT4 | Homo sapiens | Human | PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.6 | IC50 | ChEMBL;BindingDB |
| Q9H2G2 | SLK | Homo sapiens | Human | PF00069 PF12474 | 8.5 | Kd | ChEMBL |
| Q16288 | NTRK3 | Homo sapiens | Human | PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 | 8.5 | Kd | ChEMBL |
| Q04912 | MST1R | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 8.5 | IC50 | ChEMBL;BindingDB |
| Q15375 | EPHA7 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.4 | Kd | ChEMBL |
| P50613 | CDK7 | Homo sapiens | Human | PF00069 | 8.4 | Kd | ChEMBL |
| Q9HBH9 | MKNK2 | Homo sapiens | Human | PF00069 | 8.4 | Kd | ChEMBL |
| P04629 | NTRK1 | Homo sapiens | Human | PF13855 PF16920 PF07714 PF18613 | 8.4 | IC50 | ChEMBL;BindingDB |
| P29323 | EPHB2 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.4 | Kd | ChEMBL |
| Q16620 | NTRK2 | Homo sapiens | Human | PF07679 PF13855 PF16920 PF01462 PF07714 | 8.4 | Kd | ChEMBL |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.4 | IC50 | ChEMBL;BindingDB |
| P16234 | PDGFRA | Homo sapiens | Human | PF07679 PF25305 PF07714 | 8.3 | IC50 | ChEMBL;BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 8.3 | IC50 | ChEMBL;BindingDB |
| P51451 | BLK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.3 | Kd | ChEMBL |
| Q56UN5 | MAP3K19 | Homo sapiens | Human | PF00069 | 8.3 | Kd | ChEMBL |
| P21709 | EPHA1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 8.2 | Kd | ChEMBL |
| P10721 | KIT | Homo sapiens | Human | PF00047 PF07714 | 8.2 | IC50 | ChEMBL;BindingDB |
| P17948 | FLT1 | Homo sapiens | Human | PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.2 | IC50 | ChEMBL;BindingDB |
| P09619 | PDGFRB | Homo sapiens | Human | PF00047 PF13927 PF25305 PF07714 | 8.0 | IC50 | ChEMBL;BindingDB |
| P42685 | FRK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.0 | Kd | ChEMBL |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 8.0 | IC50 | ChEMBL;BindingDB |
| P54762 | EPHB1 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 7.9 | Kd | ChEMBL |
| Q02750 | MAP2K1 | Homo sapiens | Human | PF00069 | 7.9 | Kd | ChEMBL |
| Q9UQB9 | AURKC | Homo sapiens | Human | PF00069 | 7.9 | Kd | ChEMBL |
| O15146 | MUSK | Homo sapiens | Human | PF01392 PF07679 PF13927 PF07714 | 7.9 | Kd | ChEMBL |
| P36507 | MAP2K2 | Homo sapiens | Human | PF00069 | 7.9 | Kd | ChEMBL |
| P29317 | EPHA2 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 7.9 | Kd | ChEMBL;BindingDB |
| O43283 | MAP3K13 | Homo sapiens | Human | PF07714 | 7.8 | Kd | ChEMBL |
| P06239 | LCK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.8 | Kd | ChEMBL |
| P08922 | ROS1 | Homo sapiens | Human | PF00041 PF07714 | 7.8 | Ki | ChEMBL;BindingDB |
| Q9H3Y6 | SRMS | Homo sapiens | Human | PF07714 PF00017 | 7.8 | Kd | ChEMBL |
| O00444 | PLK4 | Homo sapiens | Human | PF00069 PF18190 PF18409 | 7.7 | Kd | ChEMBL |
| Q13163 | MAP2K5 | Homo sapiens | Human | PF00564 PF00069 | 7.7 | Kd | ChEMBL |
| Q13470 | TNK1 | Homo sapiens | Human | PF07714 PF22931 | 7.7 | Kd | ChEMBL |
| Q12852 | MAP3K12 | Homo sapiens | Human | PF07714 | 7.7 | Kd | ChEMBL |
| P12931 | SRC | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.6 | Kd | ChEMBL |
| Q16832 | DDR2 | Homo sapiens | Human | PF21114 PF00754 PF07714 | 7.6 | Kd | ChEMBL |
| O15197 | EPHB6 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 | 7.6 | Kd | ChEMBL |
| O94921 | CDK14 | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL |
| P08631 | HCK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.5 | Kd | ChEMBL |
| Q96Q40 | CDK15 | Homo sapiens | Human | PF00069 | 7.5 | Kd | ChEMBL |
| P07948 | LYN | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.5 | Kd | ChEMBL |
| O43353 | RIPK2 | Homo sapiens | Human | PF00619 PF07714 | 7.5 | Kd | ChEMBL |
| P42684 | ABL2 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 7.4 | Kd | ChEMBL |
| P54756 | EPHA5 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 | 7.4 | Kd | ChEMBL |
| P09769 | FGR | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.4 | Kd | ChEMBL |
| P54764 | EPHA4 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF00041 PF07714 PF07647 | 7.4 | Kd | ChEMBL |
| Q13882 | PTK6 | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.4 | Kd | ChEMBL |
| Q92918 | MAP4K1 | Homo sapiens | Human | PF00780 PF00069 | 7.4 | Kd | ChEMBL |
| Q9Y4K4 | MAP4K5 | Homo sapiens | Human | PF00780 PF00069 | 7.3 | Kd | ChEMBL |
| P00519 | ABL1 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 7.3 | Kd | ChEMBL |
| P07947 | YES1 | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.3 | Kd | ChEMBL |
| Q9NYL2 | MAP3K20 | Homo sapiens | Human | PF07714 PF07647 | 7.3 | Kd | ChEMBL |
| P14616 | INSRR | Homo sapiens | Human | PF00041 PF00757 PF07714 PF01030 | 7.3 | Kd | ChEMBL |
| O15264 | MAPK13 | Homo sapiens | Human | PF00069 | 7.3 | Kd | ChEMBL |
| Q8TBX8 | PIP4K2C | Homo sapiens | Human | PF01504 | 7.3 | Kd | ChEMBL |
| O96017 | CHEK2 | Homo sapiens | Human | PF00498 PF00069 | 7.2 | Kd | ChEMBL |
| Q99835 | SMO | Homo sapiens | Human | PF01534 PF01392 | 7.2 | Ki | ChEMBL;BindingDB |
| Q08881 | ITK | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 7.2 | Kd | ChEMBL |
| Q9UM73 | ALK | Homo sapiens | Human | PF12810 PF00629 PF07714 | 7.2 | Kd | ChEMBL |
| Q8TD08 | MAPK15 | Homo sapiens | Human | PF00069 | 7.1 | Kd | ChEMBL |
| Q9BUB5 | MKNK1 | Homo sapiens | Human | PF00069 | 7.1 | Kd | ChEMBL |
| P54753 | EPHB3 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 7.1 | Kd | ChEMBL |
| P06241 | FYN | Homo sapiens | Human | PF07714 PF00017 PF00018 | 7.1 | Kd | ChEMBL |
| Q9BWU1 | CDK19 | Homo sapiens | Human | PF00069 | 7.1 | Kd | ChEMBL |
| Q14289 | PTK2B | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 7.0 | Kd | ChEMBL |
| Q9BYT3 | STK33 | Homo sapiens | Human | PF00069 | 7.0 | Kd | ChEMBL |
| O95436 | SLC34A2 | Homo sapiens | Human | PF02690 | 7.0 | IC50 | ChEMBL |
| P54760 | EPHB4 | Homo sapiens | Human | PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 | 7.0 | Kd | ChEMBL |
| Q86Z02 | HIPK1 | Homo sapiens | Human | PF00069 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q8NE63 | HIPK4 | Homo sapiens | Human | PF00069 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q9H2X6 | HIPK2 | Homo sapiens | Human | PF00069 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q9H422 | HIPK3 | Homo sapiens | Human | PF00069 | 7.0 | IC50 | ChEMBL;BindingDB |
| P11274 | BCR | Homo sapiens | Human | PF09036 PF00168 PF19057 PF00620 PF00621 | 7.0 | Kd | ChEMBL |
| P07332 | FES | Homo sapiens | Human | PF00611 PF07714 PF00017 | 7.0 | Kd | ChEMBL |
| P29376 | LTK | Homo sapiens | Human | PF12810 PF07714 | 7.0 | Kd | ChEMBL |
| Q8IVH8 | MAP4K3 | Homo sapiens | Human | PF00780 PF00069 | 7.0 | Kd | ChEMBL |
| Q96GD4 | AURKB | Homo sapiens | Human | PF00069 | 7.0 | Kd | ChEMBL |
| P16591 | FER | Homo sapiens | Human | PF00611 PF07714 PF00017 | 6.9 | Kd | ChEMBL |
| P41240 | CSK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 6.9 | Kd | ChEMBL |
| P49336 | CDK8 | Homo sapiens | Human | PF00069 | 6.9 | Kd | ChEMBL |
| Q59H18 | TNNI3K | Homo sapiens | Human | PF12796 PF07714 | 6.9 | Kd | ChEMBL |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 6.8 | Kd | ChEMBL |
| Q9Y572 | RIPK3 | Homo sapiens | Human | PF00069 PF12721 | 6.8 | Kd | ChEMBL |
| Q00537 | CDK17 | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL |
| Q9UBE8 | NLK | Homo sapiens | Human | PF00069 | 6.8 | Kd | ChEMBL |
| Q05397 | PTK2 | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 6.8 | Kd | ChEMBL |
| Q6DT37 | CDC42BPG | Homo sapiens | Human | PF00130 PF00780 PF08826 PF25346 PF00069 PF00433 | 6.8 | Kd | ChEMBL |
| Q9NRP7 | STK36 | Homo sapiens | Human | PF13646 PF00069 | 6.8 | Kd | ChEMBL |
| Q06187 | BTK | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 6.7 | Kd | ChEMBL |
| O95819 | MAP4K4 | Homo sapiens | Human | PF00780 PF00069 | 6.7 | Kd | ChEMBL |
| P00533 | EGFR | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.7 | Kd | ChEMBL |
| P51813 | BMX | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 | 6.7 | Kd | ChEMBL |
| Q07912 | TNK2 | Homo sapiens | Human | PF09027 PF11555 PF07714 PF22931 PF14604 | 6.7 | Kd | ChEMBL |
| P06213 | INSR | Homo sapiens | Human | PF00757 PF17870 PF07714 PF01030 | 6.7 | Kd | ChEMBL |
| Q14004 | CDK13 | Homo sapiens | Human | PF00069 | 6.7 | Kd | ChEMBL |
| Q9UKE5 | TNIK | Homo sapiens | Human | PF00780 PF00069 | 6.7 | Kd | ChEMBL |
| Q8TDR2 | STK35 | Homo sapiens | Human | PF00069 | 6.6 | Kd | ChEMBL |
| Q92772 | CDKL2 | Homo sapiens | Human | PF00069 | 6.6 | Kd | ChEMBL |
| Q07002 | CDK18 | Homo sapiens | Human | PF00069 | 6.6 | Kd | ChEMBL |
| Q15569 | TESK1 | Homo sapiens | Human | PF07714 | 6.6 | Kd | ChEMBL |
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 6.5 | Kd | ChEMBL |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 6.5 | Kd | ChEMBL |
| P42680 | TEC | Homo sapiens | Human | PF00779 PF00169 PF07714 PF00017 PF00018 | 6.5 | Kd | ChEMBL |
| Q16539 | MAPK14 | Homo sapiens | Human | PF00069 | 6.5 | Kd | ChEMBL |
| Q9Y5S2 | CDC42BPB | Homo sapiens | Human | PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 | 6.5 | Kd | ChEMBL |
| Q16584 | MAP3K11 | Homo sapiens | Human | PF07714 PF14604 | 6.5 | Kd | ChEMBL;BindingDB |
| Q9Y616 | IRAK3 | Homo sapiens | Human | PF00531 PF00069 | 6.4 | Kd | ChEMBL |
| P53778 | MAPK12 | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL |
| P08069 | IGF1R | Homo sapiens | Human | PF00757 PF07714 PF01030 | 6.4 | Kd | ChEMBL |
| P33981 | TTK | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL |
| O14965 | AURKA | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL |
| Q6PHR2 | ULK3 | Homo sapiens | Human | PF04212 PF00069 | 6.3 | Kd | ChEMBL |
| Q8TD19 | NEK9 | Homo sapiens | Human | PF00069 PF25390 | 6.3 | Kd | ChEMBL |
| Q9UQ88 | CDK11A | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| Q6XUX3 | DSTYK | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| P42681 | TXK | Homo sapiens | Human | PF07714 PF00017 PF00018 | 6.3 | Kd | ChEMBL |
| Q02779 | MAP3K10 | Homo sapiens | Human | PF07714 PF14604 | 6.3 | Kd | ChEMBL |
| O43318 | MAP3K7 | Homo sapiens | Human | PF07714 | 6.3 | Kd | ChEMBL |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| Q8N5S9 | CAMKK1 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| P04626 | ERBB2 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.2 | Kd | ChEMBL |
| Q15303 | ERBB4 | Homo sapiens | Human | PF00757 PF14843 PF07714 PF01030 PF21314 | 6.2 | Kd | ChEMBL |
| P21127 | CDK11B | Homo sapiens | Human | PF00069 | 6.2 | Kd | ChEMBL |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 6.2 | Kd | ChEMBL |
| Q5VT25 | CDC42BPA | Homo sapiens | Human | PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 | 6.2 | Kd | ChEMBL |
| P45984 | MAPK9 | Homo sapiens | Human | PF00069 | 6.2 | Kd | ChEMBL |
| P53667 | LIMK1 | Homo sapiens | Human | PF00412 PF00595 PF07714 | 6.2 | Kd | ChEMBL |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 6.2 | Kd | ChEMBL |
| Q8WXR4 | MYO3B | Homo sapiens | Human | PF00612 PF00063 PF00069 | 6.2 | Kd | ChEMBL |
| Q13131 | PRKAA1 | Homo sapiens | Human | PF16579 PF21147 PF00069 | 6.1 | Kd | ChEMBL |
| Q15759 | MAPK11 | Homo sapiens | Human | PF00069 | 6.1 | Kd | ChEMBL |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 6.1 | Kd | ChEMBL |
| Q9UHD2 | TBK1 | Homo sapiens | Human | PF00069 PF18394 PF18396 | 6.1 | Kd | ChEMBL |
| Q13546 | RIPK1 | Homo sapiens | Human | PF00531 PF07714 | 6.1 | Kd | ChEMBL |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 6.1 | Kd | ChEMBL |
| P57078 | RIPK4 | Homo sapiens | Human | PF12796 PF13637 PF00069 | 6.0 | Kd | ChEMBL |
| Q00536 | CDK16 | Homo sapiens | Human | PF00069 | 6.0 | Kd | ChEMBL |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 6.0 | Kd | ChEMBL |
| Q9BQI3 | EIF2AK1 | Homo sapiens | Human | PF22949 PF00069 | 6.0 | Kd | ChEMBL |
| P80192 | MAP3K9 | Homo sapiens | Human | PF07714 PF14604 | 6.0 | Kd | ChEMBL |
| P62344 | CDPK1 | Plasmodium falciparum (isolate 3D7) | Pathogen | PF13499 PF00069 | 6.6 | Kd | ChEMBL |