Molecule Details
| InChIKey | CXJITJGGCTWHEG-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-[3-[4-Amino-5-[2-(3,5-dimethoxyphenyl)ethynyl]-4a,7a-dihydropyrrolo[2,3-d]pyrimidin-7-yl]azetidin-1-yl]prop-2-en-1-one |
| Canonical SMILES | C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 9.23 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 10.0 | IC50 | ChEMBL;BindingDB |
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 8.9 | IC50 | ChEMBL;BindingDB |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 8.8 | IC50 | ChEMBL;BindingDB |