InChIKey	CUIHSIWYWATEQL-UHFFFAOYSA-N
Compound Name	Pazopanib
Canonical SMILES	Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	61
Pfam Stratification	Cross-Family
Avg pChEMBL	6.68
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB06589
Drug Name	Pazopanib
CAS Number	444731-52-6
Groups	approved investigational
ATC Codes	L01EX03
Description	Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.

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Categories: Amides Angiogenesis Inhibitors Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hepatotoxic Agents Heterocyclic Compounds, Fused-Ring Immunosuppressive Agents Kinase Inhibitor Moderate Risk QTc-Prolonging Agents Narrow Therapeutic Index Drugs OATP1B1/SLCO1B1 Inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Protein Kinase Inhibitors Pyrazoles QTc Prolonging Agents Receptors, Vascular Endothelial Growth Factor, antagonists & inhibitors Sulfones Sulfur Compounds Tyrosine Kinase Inhibitors UGT1A1 Inhibitors

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Cross-references: BindingDB: 26474 ChEBI: 71219 CHEMBL477772 ChemSpider: 8289501 Drugs Product Database (DPD): 20595 D05380 PubChem:10113978 PubChem:175427074 RxCUI: 714438 Wikipedia: Pazopanib ZINC: ZINC000011617039