Molecule Details
| InChIKey | CTETYYAZBPJBHE-UHFFFAOYSA-N |
|---|---|
| Compound Name | Haloprogin |
| Canonical SMILES | Clc1cc(Cl)c(OCC#CI)cc1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 11 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.37 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00793 |
|---|---|
| Drug Name | Haloprogin |
| CAS Number | 777-11-7 |
| Groups | approved withdrawn |
| ATC Codes | D01AE11 |
| Description | Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the ... |
Categories: Anti-Infective Agents Antifungal Agents Antifungals for Dermatological Use Antifungals for Topical Use Benzene Derivatives Dermatologicals Ethers Phenols
Cross-references: BindingDB: 50194601 ChEBI: 5614 CHEMBL1289 ChemSpider: 3440 D00339 PharmGKB: PA164768737 PubChem:3561 PubChem:46504892 RxCUI: 26422 Therapeutic Targets Database: DAP001332 Wikipedia: Haloprogin ZINC: ZINC000001530649
Target Activities (11)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P0DMS8 | ADORA3 | Homo sapiens | Human | PF00001 | 6.8 | IC50 | ChEMBL |
| P35462 | DRD3 | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.4 | IC50 | ChEMBL |
| P21728 | DRD1 | Homo sapiens | Human | PF00001 | 6.4 | IC50 | ChEMBL |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| P41145 | OPRK1 | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| P21452 | TACR2 | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| Q14376 | GALE | Homo sapiens | Human | PF16363 | 6.3 | IC50 | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 6.2 | IC50 | ChEMBL |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |