Molecule Details
| InChIKey | CSZAJEXPQFERTK-UHFFFAOYSA-N |
|---|---|
| Compound Name | 4-[5-(1-Ethylpyrazol-4-yl)benzimidazol-1-yl]-2,6-dimethoxybenzoic acid |
| Canonical SMILES | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)O)c(OC)c2)cn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.97 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9Y2K2 | SIK3 | Homo sapiens | Human | PF00069 PF23312 | 7.9 | IC50 | ChEMBL |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 7.7 | IC50 | ChEMBL |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 7.6 | IC50 | ChEMBL |
| O43741 | PRKAB2 | Homo sapiens | Human | PF16561 PF04739 | 7.2 | IC50 | ChEMBL |
| P54619 | PRKAG1 | Homo sapiens | Human | PF00571 | 7.2 | IC50 | ChEMBL |
| Q13131 | PRKAA1 | Homo sapiens | Human | PF16579 PF21147 PF00069 | 7.2 | IC50 | ChEMBL |
| P36897 | TGFBR1 | Homo sapiens | Human | PF01064 PF00069 PF08515 | 6.7 | IC50 | ChEMBL |
| P00519 | ABL1 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 6.3 | IC50 | ChEMBL |
| P37173 | TGFBR2 | Homo sapiens | Human | PF08917 PF07714 | 6.1 | IC50 | ChEMBL |
| P07948 | LYN | Homo sapiens | Human | PF07714 PF00017 PF00018 | 6.0 | IC50 | ChEMBL |