Molecule Details
InChIKeyCSGQVNMSRKWUSH-IAGOWNOFSA-N
Compound NameBms-690514
Canonical SMILESCOc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL6.62
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB11665
Drug NameBMS-690514
CAS Number859853-30-8
Groups investigational
ATC Codes nan
DescriptionBMS-690514 has been investigated for the treatment of Breast Cancer.
Categories: Carbon Radioisotopes
Cross-references: BindingDB: 185148 CHEMBL3545396 ChemSpider: 9524108 PubChem:11349170 PubChem:347828034 ZINC: ZINC000043152599
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
O14976 GAK Homo sapiens Human PF00069 PF10409 9.5 Kd ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.5 Kd ChEMBL
P42684 ABL2 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.4 Kd ChEMBL
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 7.3 Kd ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.9 Kd ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.8 Kd ChEMBL
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 6.7 Kd ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.7 Kd ChEMBL;BindingDB
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.5 Kd ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.3 Kd ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Kd ChEMBL
Q99759 MAP3K3 Homo sapiens Human PF00564 PF00069 6.3 Kd ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.2 Kd ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Kd ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.2 Kd ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 6.1 Kd ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Kd ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Kd ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.0 Kd ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.0 Kd BindingDB
Q13163 MAP2K5 Homo sapiens Human PF00564 PF00069 6.0 Kd ChEMBL
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P00533 EGFR Epidermal growth factor receptor inhibitor targets
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 inhibitor targets
P35968 KDR Vascular endothelial growth factor receptor 2 inhibitor targets
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 inhibitor targets