Molecule Details
| InChIKey | CSAZFNFHNZMQCE-LJQANCHMSA-N |
|---|---|
| Compound Name | PCSK9 inhjbitor 4g |
| Canonical SMILES | Cc1cccnc1N(C(=O)N1CCC(c2cnn3cccnc23)CC1)[C@@H]1CCCNC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 78 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.04 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (78)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P05386 | RPLP1 | Homo sapiens | Human | PF00428 | 6.0 | IC50 | ChEMBL |
| P05388 | RPLP0 | Homo sapiens | Human | PF00428 PF00466 PF17777 | 6.0 | IC50 | ChEMBL |
| P08708 | RPS17 | Homo sapiens | Human | PF00833 | 6.0 | IC50 | ChEMBL |
| P08865 | RPSA | Homo sapiens | Human | PF16122 PF00318 | 6.0 | IC50 | ChEMBL |
| P15880 | RPS2 | Homo sapiens | Human | PF00333 PF03719 | 6.0 | IC50 | ChEMBL |
| P18077 | RPL35A | Homo sapiens | Human | PF01247 | 6.0 | IC50 | ChEMBL |
| P18124 | RPL7 | Homo sapiens | Human | PF00327 PF08079 | 6.0 | IC50 | ChEMBL |
| P18621 | RPL17 | Homo sapiens | Human | PF00237 | 6.0 | IC50 | ChEMBL |
| P22090 | RPS4Y1 | Homo sapiens | Human | PF16121 PF00467 PF00900 PF08071 | 6.0 | IC50 | ChEMBL |
| P23396 | RPS3 | Homo sapiens | Human | PF07650 PF00189 | 6.0 | IC50 | ChEMBL |
| P25398 | RPS12 | Homo sapiens | Human | PF01248 | 6.0 | IC50 | ChEMBL |
| P26373 | RPL13 | Homo sapiens | Human | PF01294 | 6.0 | IC50 | ChEMBL |
| P27635 | RPL10 | Homo sapiens | Human | PF00252 | 6.0 | IC50 | ChEMBL |
| P30050 | RPL12 | Homo sapiens | Human | PF00298 PF03946 | 6.0 | IC50 | ChEMBL |
| P32969 | RPL9 | Homo sapiens | Human | PF00347 | 6.0 | IC50 | ChEMBL |
| P35268 | RPL22 | Homo sapiens | Human | PF01776 | 6.0 | IC50 | ChEMBL |
| P36578 | RPL4 | Homo sapiens | Human | PF14374 PF00573 | 6.0 | IC50 | ChEMBL |
| P39019 | RPS19 | Homo sapiens | Human | PF01090 | 6.0 | IC50 | ChEMBL |
| P39023 | RPL3 | Homo sapiens | Human | PF00297 | 6.0 | IC50 | ChEMBL |
| P40429 | RPL13A | Homo sapiens | Human | PF00572 | 6.0 | IC50 | ChEMBL |
| P42677 | RPS27 | Homo sapiens | Human | PF01667 | 6.0 | IC50 | ChEMBL |
| P42766 | RPL35 | Homo sapiens | Human | PF00831 | 6.0 | IC50 | ChEMBL |
| P46776 | RPL27A | Homo sapiens | Human | PF00828 | 6.0 | IC50 | ChEMBL |
| P46777 | RPL5 | Homo sapiens | Human | PF14204 PF17144 | 6.0 | IC50 | ChEMBL |
| P46778 | RPL21 | Homo sapiens | Human | PF01157 | 6.0 | IC50 | ChEMBL |
| P46779 | RPL28 | Homo sapiens | Human | PF01778 | 6.0 | IC50 | ChEMBL |
| P46781 | RPS9 | Homo sapiens | Human | PF00163 PF01479 | 6.0 | IC50 | ChEMBL |
| P46782 | RPS5 | Homo sapiens | Human | PF00177 | 6.0 | IC50 | ChEMBL |
| P46783 | RPS10 | Homo sapiens | Human | PF03501 | 6.0 | IC50 | ChEMBL |
| P47914 | RPL29 | Homo sapiens | Human | PF01779 | 6.0 | IC50 | ChEMBL |
| P49207 | RPL34 | Homo sapiens | Human | PF01199 | 6.0 | IC50 | ChEMBL |
| P50914 | RPL14 | Homo sapiens | Human | PF01929 | 6.0 | IC50 | ChEMBL |
| P60866 | RPS20 | Homo sapiens | Human | PF00338 | 6.0 | IC50 | ChEMBL |
| P61247 | RPS3A | Homo sapiens | Human | PF01015 | 6.0 | IC50 | ChEMBL |
| P61254 | RPL26 | Homo sapiens | Human | PF00467 PF16906 | 6.0 | IC50 | ChEMBL |
| P61313 | RPL15 | Homo sapiens | Human | PF00827 | 6.0 | IC50 | ChEMBL |
| P61353 | RPL27 | Homo sapiens | Human | PF00467 PF01777 | 6.0 | IC50 | ChEMBL |
| P61513 | RPL37A | Homo sapiens | Human | PF01780 | 6.0 | IC50 | ChEMBL |
| P61927 | RPL37 | Homo sapiens | Human | PF01907 | 6.0 | IC50 | ChEMBL |
| P62081 | RPS7 | Homo sapiens | Human | PF01251 | 6.0 | IC50 | ChEMBL |
| P62241 | RPS8 | Homo sapiens | Human | PF01201 | 6.0 | IC50 | ChEMBL |
| P62244 | RPS15A | Homo sapiens | Human | PF00410 | 6.0 | IC50 | ChEMBL |
| P62249 | RPS16 | Homo sapiens | Human | PF00380 | 6.0 | IC50 | ChEMBL |
| P62263 | RPS14 | Homo sapiens | Human | PF00411 | 6.0 | IC50 | ChEMBL |
| P62266 | RPS23 | Homo sapiens | Human | PF00164 | 6.0 | IC50 | ChEMBL |
| P62269 | RPS18 | Homo sapiens | Human | PF00416 | 6.0 | IC50 | ChEMBL |
| P62273 | RPS29 | Homo sapiens | Human | PF00253 | 6.0 | IC50 | ChEMBL |
| P62277 | RPS13 | Homo sapiens | Human | PF08069 PF00312 | 6.0 | IC50 | ChEMBL |
| P62280 | RPS11 | Homo sapiens | Human | PF00366 PF16205 | 6.0 | IC50 | ChEMBL |
| P62424 | RPL7A | Homo sapiens | Human | PF01248 | 6.0 | IC50 | ChEMBL |
| P62701 | RPS4X | Homo sapiens | Human | PF16121 PF00467 PF00900 PF08071 | 6.0 | IC50 | ChEMBL |
| P62750 | RPL23A | Homo sapiens | Human | PF00276 PF03939 | 6.0 | IC50 | ChEMBL |
| P62753 | RPS6 | Homo sapiens | Human | PF01092 | 6.0 | IC50 | ChEMBL |
| P62829 | RPL23 | Homo sapiens | Human | PF00238 | 6.0 | IC50 | ChEMBL |
| P62841 | RPS15 | Homo sapiens | Human | PF00203 | 6.0 | IC50 | ChEMBL |
| P62847 | RPS24 | Homo sapiens | Human | PF01282 | 6.0 | IC50 | ChEMBL |
| P62851 | RPS25 | Homo sapiens | Human | PF03297 | 6.0 | IC50 | ChEMBL |
| P62854 | RPS26 | Homo sapiens | Human | PF01283 | 6.0 | IC50 | ChEMBL |
| P62857 | RPS28 | Homo sapiens | Human | PF01200 | 6.0 | IC50 | ChEMBL |
| P62861 | FAU | Homo sapiens | Human | PF04758 PF00240 | 6.0 | IC50 | ChEMBL |
| P62888 | RPL30 | Homo sapiens | Human | PF01248 | 6.0 | IC50 | ChEMBL |
| P62891 | RPL39 | Homo sapiens | Human | PF00832 | 6.0 | IC50 | ChEMBL |
| P62899 | RPL31 | Homo sapiens | Human | PF01198 | 6.0 | IC50 | ChEMBL |
| P62906 | RPL10A | Homo sapiens | Human | PF00687 | 6.0 | IC50 | ChEMBL |
| P62910 | RPL32 | Homo sapiens | Human | PF01655 | 6.0 | IC50 | ChEMBL |
| P62913 | RPL11 | Homo sapiens | Human | PF00281 PF00673 | 6.0 | IC50 | ChEMBL |
| P62917 | RPL8 | Homo sapiens | Human | PF03947 PF00181 | 6.0 | IC50 | ChEMBL |
| P62945 | RPL41 | Homo sapiens | Human | PF05162 | 6.0 | IC50 | ChEMBL |
| P62979 | RPS27A | Homo sapiens | Human | PF01599 PF00240 | 6.0 | IC50 | ChEMBL |
| P63173 | RPL38 | Homo sapiens | Human | PF01781 | 6.0 | IC50 | ChEMBL |
| P63220 | RPS21 | Homo sapiens | Human | PF01249 | 6.0 | IC50 | ChEMBL |
| P83731 | RPL24 | Homo sapiens | Human | PF01246 | 6.0 | IC50 | ChEMBL |
| P83881 | RPL36A | Homo sapiens | Human | PF00935 | 6.0 | IC50 | ChEMBL |
| P84098 | RPL19 | Homo sapiens | Human | PF01280 PF25476 | 6.0 | IC50 | ChEMBL |
| Q02543 | RPL18A | Homo sapiens | Human | PF01775 | 6.0 | IC50 | ChEMBL |
| Q02878 | RPL6 | Homo sapiens | Human | PF01159 PF03868 | 6.0 | IC50 | ChEMBL |
| Q07020 | RPL18 | Homo sapiens | Human | PF17135 | 6.0 | IC50 | ChEMBL |
| Q9Y3U8 | RPL36 | Homo sapiens | Human | PF01158 | 6.0 | IC50 | ChEMBL |