N-(4-chloro-2-methyl-3-pyridinyl)-2-[[6-[[4-(2-hydroxyethyl)piperazin-1-yl]amino]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

InChIKey	`CRLZGLXSANQWFT-UHFFFAOYSA-N`
Compound Name	N-(4-chloro-2-methyl-3-pyridinyl)-2-[[6-[[4-(2-hydroxyethyl)piperazin-1-yl]amino]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
Canonical SMILES	`Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	6
Pfam Stratification	Cross-Family
Avg pChEMBL	7.79
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	9.0	IC50	ChEMBL
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	9.0	IC50	ChEMBL
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	7.5	IC50	ChEMBL
P10721	KIT	Homo sapiens	Human	PF00047 PF07714	7.4	IC50	ChEMBL
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	7.2	IC50	ChEMBL
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	6.6	IC50	ChEMBL