Molecule Details
| InChIKey | CQZHACPWDPHMKC-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-(3,5-difluoro-4-{[6-(methylamino)-4-pyrimidinyl]oxy}phenyl)-N'-[3-(trifluoromethyl)phenyl]urea |
| Canonical SMILES | CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2F)ncn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.1 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q59H18 | TNNI3K | Homo sapiens | Human | PF12796 PF07714 | 7.7 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 7.3 | IC50 | ChEMBL;BindingDB |
| Q16539 | MAPK14 | Homo sapiens | Human | PF00069 | 6.3 | IC50 | ChEMBL;BindingDB |