Molecule Details
| InChIKey | CQXADFVORZEARL-UHFFFAOYSA-N |
|---|---|
| Compound Name | Rilmenidine |
| Canonical SMILES | C1COC(NC(C2CC2)C2CC2)=N1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.93 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB11738 |
|---|---|
| Drug Name | Rilmenidine |
| CAS Number | 54187-04-1 |
| Groups | approved withdrawn |
| ATC Codes | C02AC06 |
| Description | Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease. |
Categories: Adrenergic Agents Adrenergic Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Antiadrenergic Agents, Centrally Acting Antihypertensive Agents Autonomic Agents Cardiovascular Agents Imidazoline Receptor Agonists Neurotransmitter Agents Oxazoles Peripheral Nervous System Agents Sympatholytics
Cross-references: BindingDB: 50070328 ChEBI: 8862 CHEMBL289480 ChemSpider: 61963 C11120 PubChem:68712 PubChem:347828096 RxCUI: 55679 Wikipedia: Rilmenidine ZINC: ZINC000000009708
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9Y2I1 | NISCH | Homo sapiens | Human | PF25625 PF23142 PF00787 | 7.2 | Ki | ChEMBL;BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 7.2 | Ki | ChEMBL;BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.7 | Ki | ChEMBL;BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 6.6 | Ki | ChEMBL;BindingDB |